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KMID : 0617219970080010037
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Duksung Bulletin Phamaceutical Sciences
1997 Volume.8 No. 1 p.37 ~ p.43
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Effects of Crystal Modification of Cephalothin Sodium on Dissolution and Stability
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Abstract
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Investigation of polymorphism has become a requirement in the pharmaceutical industry because the physical properties and bioavailabilities of crystalline drugs depend on their polymorphic form. Five polymorphic modifications and one pseudopolymorphic modification of cephalothin sodium were prepared by recrystallization, and characterized by UV spectrophotometer. DSC. TGA and X-ray crystallography. The solubilities of all modifications were examined by the dissolution test. Form 4 and 1 showed higher solubilities than any other crystal forms. The modifications were also investigated for their stability after storage of 2 months at 100％, 76％, 52％ and 0％ humidity.
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